Computation of complete human blood circulation and its applications

Computational fluid dynamics (CFD) has become a promising tool to understand the initiation and progression of vascular disease. Although detailed mechanisms have not been completely understood, it is believed that the complex hemodynamic flow patterns and hemodynamic forces in an abnormal blood vessel play an important role in the initial formation, continued growth, and eventual rupture of aneurysms. However, because large computer resources are required to simulate a complex three-dimension (3D) blood circulation network, calculations are often restricted to the investigation of a particular vascular segment. This approach poses a major difficulty, as the conditions at both inlet and outlets are generally not known, and the solution is sensitive to the choice of these conditions. A remedy to this problem is to use a multiscale approach by employing a low fidelity model for the complete human blood circulation to generate the boundary conditions needed for the 3D simulation.

In this short course, the low fidelity model for the complete human circulatory system is introduced and the method is based on recent work by the author and others. This work includes a one-dimension (1D) network simulation of major arterial and venous networks and zero-dimension (0D) modeling of the circulation in the heart, lungs, and various other human organs. This simulation approach enables a complete blood flow cycle driven by the heart pump, and therefore no boundary condition is required. The 0D-1D simulation of the complete vessel network is introduced to couple with a zonal 3D simulation of a vessel segment. This approach can improve the localized details of the flow quantities, such as velocity, pressure, and wall shear stress, by eliminating the need for the undesirable boundary conditions. We will validate the models with data reported in the literature, in-house experiments, and clinical data.

Time: 14:20-16:20, Mon; 09:10-11:10, Tue; 09:10-11:10, Wed, December 11 - 13, 2017
Room: 308, Mathematics Research Center Building (ori. New Math. Bldg.)
Speaker: George P. G. Huang  ( Department of Mechanical and Materials Engineering, Wright State University, USA )
Organizer: Tony Wen-Hann Sheu  ( Department of Engineering Science and Ocean Engineering, National Taiwan University )